Fujitsu ScanSnap S300 Operator's Manual page 153

6.1 Using ScanSnap Manager
5. Press the [SCAN] button .
⇒
The document is scanned in the Simplex mode.
To return the setting to the Duplex mode, select [Duplex scan] in Step 2. The
HINT
selected setting is applied to further scans unless it is changed again.
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ScanSnap S300 Operator's Guide